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design synthesis and anti

Author De-pu Wang,Kai-li Liu,Xin-yang Li,Guo-qing Lu,Wen-han Xue,Xin-hua Qian,Kamara Mohamed O,Fan-hPublish Year 2021Design,synthesis and biological evaluation of novel

Sep 01,2020·Bedaquiline (TMC207),a typical diarylquinoline anti-tuberculosis drug,has been approved by FDA to specifically treat MDR-TB.Herein we describe design,synthesis,and in vitro biological evaluation against Mycobacterium tuberculosis of a series of triaryldimethylaminobutan-2-ol derivatives obtaining from the structural modification of TMC207.Author Hang Xie,Jian-Jia Liang,Ya-Lei Wang,Tian-Xing Hu,Jin-Yi Wang,Rui-Hua Yang,Jun-Ke Yan,Qiu-RongPublish Year 2020Design,Synthesis,and Anti-ToCV Activity of Novel 4(3H To develop efficient anti-ToCV agents,some novel 4(3H)-quinazolinone derivatives containing dithioacetal were designed and synthesized,and their anti-ToCV activities were evaluated by microscale thermophoresis (MST) using ToCV coat protein (ToCV-CP) as a new target.The results showed that some compounds had a strong binding capacity to ToCV-CP.

Author Mi Zhang,Jing Liang,Shi-Kun Jiang,Ling Xu,Yan-Ling Wu,Annoor Awadasseid,Xiao-Yin Zhao,Xu-QionPublish Year 2020The design,synthesis and anti-tumor mechanism study of

Oct 15,2020·The design,synthesis and anti-tumor mechanism study of new androgen receptor degrader Author links open overlay panel Hang Xie a b c 1 Jian-Jia Liang d 1 Ya-Lei Wang a b c Tian-Xing Hu a b c Jin-Yi Wang a b c Rui-Hua Yang a b c Jun-Ke Yan a b c Qiu-Rong Zhang a b c Xia Xu a b Hong-Min Liu a b c Yu Ke a b cCited by 10Publish Year 2019Author Ji-Seong Yoon,Gyudong Kim,Gyudong Kim,Dnyandev B Jarhad,Hong-Rae Kim,Young-Sup Shin,Shuhao Qu,Design,synthesis and anti-influenza A virus activity of Jun 01,2020·In conclusion,we reported the design and synthesis of four 2,4-disubstituted quinazoline series containing various amide moieties and tested their anti-influenza A/WSN/33 (H1N1) virus activities.Many of them exhibit potent in vitro anti-IAV activity and low cytotoxicity (CC 50 >100 M).

Cited by 1Publish Year 2019Author Apeng Wang,Shuo Wu,Zeyu Tao,Xiaoning Li,Kai Lv,Chao Ma,Yuhuan Li,Linhu Li,Mingliang LiuDesign,synthesis,and in vitro and in vivo anti

Design,synthesis,and in vitro and in vivo anti-angiogenesis study of a novel vascular endothelial growth factor receptor-2 (VEGFR-2) inhibitor based on 1,2,3-triazole scaffold Author links open overlay panel De-pu Wang a 1 Kai-li Liu a 1 Xin-yang Li a b Guo-qing Lu a Wen-han Xue a Xin-hua Qian a Kamara Mohamed O a Fan-hao Meng aCited by 1Publish Year 2020Author Gangqiang Yang,Meng Gao,Yixiao Sun,Conghui Wang,Xiaojuan Fang,Hongyan Gao,Wenshuang Diao,Hui Design,synthesis,and anti-tumor evaluation of novel Apr 01,2009·Design,synthesis,and anti-tumor evaluation of novel symmetrical bis-benzimidazoles Author links open overlay panel Yan-Hui Yang a Mao-Sheng Cheng a Qing-He Wang a Han Nie a Na Liao a Jian Wang a Hong Chen b

Cited by 1Publish Year 2020Author Guangcheng Zu,Xiuhai Gan,Dandan Xie,Huanyu Yang,Awei Zhang,Shaoyuan Li,Deyu Hu,Baoan SongDesign,synthesis and anti-inflammatory activity of 3

Sep 15,2020·Design,synthesis and anti-inflammatory activity of 3-amino acid derivatives of ocotillol-type sapogenins.Author links open overlay panel Gangqiang Yang a 1 Meng Gao a 1 Yixiao Sun a 1 Conghui Wang a Xiaojuan Fang a Hongyan Gao a Wenshuang Diao a Hui Yu b.Show more.Share.Cite.Cited by 1Publish Year 2020Author Minghua Wang,Guoning Zhang,Yujia Wang,Juxian Wang,Mei Zhu,Shan Cen,Yucheng WangDesign,Synthesis,and Anti-HBV Activity of New Bis(l A series of bis(l-amino acid) ester prodrugs of tenofovir (TFV) were designed and synthesized as new anti-HBV agents in this work.Four compounds 11,12a,12d,and 13b displayed better anti-HBV activity (IC50 0.714.22 M) than the parent drug TFV.The most active compound 11 (IC50 0.71 M),a bis(l-valine) ester prodrug of TFV,was found to have obviously greater AUC0,Cmax,and F

Cited by 32Publish Year 2009Author Yan-Hui Yang,Mao-Sheng Cheng,Qing-He Wang,Han Nie,Na Liao,Jian Wang,Hong ChenDesign,Synthesis,and Anti-RNA Virus Activity of 6

The 6-fluorinated aristeromycins were designed as dual-target antiviral compounds aimed at inhibiting both the viral RNA-dependent RNA polymerase (RdRp) and the host cell S-adenosyl-l-homocysteine (SAH) hydrolase,which would indirectly target capping of viral RNA.The introduction of a fluorine at the 6-position enhanced the inhibition of SAH hydrolase and the activity against RNA Design,Synthesis,Molecular modeling and Anti-HIV Assay Dec 09,2019·Design,Synthesis,Molecular modeling and Anti-HIV Assay of novel Quinazolinone Incorporated Coumarin Derivatives.Safakish M(1),Hajimahdi Z(1),Aghasadeghi MR(2),Vahabpour R(3),Zarghi A(1).Author information (1)Department of Medicinal Chemistry,School of Pharmacy,Shahid Beheshti University of Medical Sciences,Tehran.Iran.

Design,Synthesis,and Anti-RNA Virus Activity of 6

Design,Synthesis,and Anti-RNA Virus Activity of 6-Fluorinated-Aristeromycin Analogues but the synthesis and biological activity of (±)-6,6-diuoroaristeromycin was not reported,despite the fact that the structure was claimed in the patent.18b Thus,we set out toDesign,Synthesis,and Anti-ToCV Activity of Novel 4(3 H Design,Synthesis,and Anti-ToCV Activity of Novel 4(3 H)-Quinazolinone Derivatives Bearing Dithioacetal Moiety J Agric Food Chem.2020 May 20;68(20):5539-5544.doi 10.1021/acs.jafc.0c00086.Epub 2020 May 8.Authors Guangcheng Zu 1

Design,Synthesis,and Anti-ToCV Activity of Novel 4(3H

Design,Synthesis,and Anti-ToCV Activity of Novel 4(3H)-Quinazolinone Derivatives Bearing Dithioacetal Moiety Guangcheng Zu State Key Laboratory Breeding Base of Green Pesticide and Agricultural Bioengineering,Key Laboratory of Green Pesticide and Agricultural Bioengineering,Ministry of Education,Guizhou University,Huaxi District,Guiyang Design,Synthesis,and Anti-leukemic Activity of Design,Synthesis,and Anti-leukemic Activity of Stereochemically Defined Constrained Analogs of FTY720 (Gilenya) ACS Med Chem Lett.2013 Oct 10;4(10):969-973.doi 10.1021/ml4002425.Authors Rebecca Fransson 1 ,Alison N McCracken,Bin Chen,Ryan J McMonigle,Aimee L Edinger,Stephen Hanessian.Affiliation 1 Department

Design,Synthesis,and Antiviral Activities of Coumarin

Design,synthesis and anti-TMV activity of novel -aminophosphonate derivatives containing a chalcone moiety that induce resistance against plant disease and target the TMV coat protein.Pesticide Biochemistry and Physiology 2020 ,,104749.Design,Synthesis,and Biological Evaluation of 2-(2-Bromo Design,Synthesis,and Biological Evaluation of 2-(2-Bromo-3-nitrophenyl)-5-phenyl-1,3,4-oxadiazole Derivatives as Possible Anti-Breast Cancer Agents Chem Biodivers.2020 Feb;17(2):e1900659.doi 10.1002/cbdv.201900659.Epub 2020 Jan 29.Authors Arjun H Ananth 1

Design,Synthesis,and Biological Evaluation of

Design,synthesis and biological evaluation of quinoline-indole derivatives as anti-tubulin agents targeting the colchicine binding site.European Journal of Medicinal Chemistry 2019 ,163 ,428-442.Design,Synthesis,and Biological Evaluation of Design,synthesis,and biological evaluation of hydantoin bridged analogues of combretastatin A-4 as potential anticancer agents.Bioorganic Medicinal Chemistry 2017,25 (24),6623-6634.DOI 10.1016/j.bmc.2017.10.045.Qile Xu,Maolin Sun,Zhaoshi Bai,Yueting Wang,Yue Wu,Haiqiu Tian,Daiying Zuo,Qi Guan,Kai Bao,Yingliang Wu,Weige Zhang.

Design,Synthesis,and Biological Evaluation of Itaconic

Mar 14,2019·Accordingly,a series of itaconic acid derivatives were designed and synthesized by adopting a rational design strategy to obtain more potent anti-influenza agents.The results of an in vitro pharmacological study showed that compounds 4 and 8 exhibited the most potent anti-IAV effect with half-maximal effective concentration values of 0.14 and 0.11 M,respectively,in Madin-Darby canineDesign,Synthesis,and Evaluation of Anti-HBV Activity of Design,Synthesis,and Evaluation of Anti-HBV Activity of Hybrid Molecules of Entecavir and Adefovir Exomethylene Acycloguanine Nucleosides and Their Monophosphate Derivatives Nucleosides Nucleotides Nucleic Acids.2015;34(8):590-602.doi 10.1080/15257770.2015.1037456.

Design,synthesis and anti--lactamase activity for new

Jan 24,2021·-Lactams are the most effective antibiotics for the treatment of infectious diseases.Unfortunately,the bacterial -lactamase breaks down the -lactDesign,synthesis and anti-MRSA activities of Request PDF Design,synthesis and anti-MRSA activities of cycloberberine derivatives with a novel chemical scaffold 9-Acetoxycycloberberine (1) with a unique skeleton was first identified to

Design,synthesis and anti-MRSA activities of

Request PDF Design,synthesis and anti-MRSA activities of cycloberberine derivatives with a novel chemical scaffold 9-Acetoxycycloberberine (1) with a unique skeleton was first identified to Design,synthesis and anti-cancer activity of pyrrole Design,synthesis and anti-cancer activity of pyrrole-imidazole polyamides through target-downregulation of c-kit gene expression Eur J Med Chem.2020 Dec 1;207:112704.doi 10.1016/j.ejmech.2020.112704.Epub 2020 Aug 5.Authors Mi Zhang 1

Design,synthesis and anti-mycobacterial activity

Herein we report the design and synthesis of a series of novel benzofuran-isatin hybrids,and in vitro evaluation of their anti-mycobacterial activity against both drug-susceptible and multi-drug resistant (MDR) Mycobacterium tuberculosis (MTB) strains.In parallel,cytotoxicity of these hybrids wasDesign,synthesis and biological evaluation of 2-quinolyl Jan 23,2021·DESIGN,SYNTHESIS AND BIOLOGICAL EVALUATION OF 2-QUINOLYL-1,3-TROPOLONE DERIVATIVES AS NEW ANTI-CANCER AGENTS.by Redazione 23 Gennaio 2021 0 6 (AGENPARL) LONDON (UNITED KINGDOM),sab 23 gennaio 2021 .RSC Adv.,2021,11,4555-4571 DOI 10.1039/D0RA10610K,Paper.Open Access

Design,synthesis and biological evaluation of 2-quinolyl

Jan 23,2021·DESIGN,SYNTHESIS AND BIOLOGICAL EVALUATION OF 2-QUINOLYL-1,3-TROPOLONE DERIVATIVES AS NEW ANTI-CANCER AGENTS.by Redazione 23 Gennaio 2021 0 6 (AGENPARL) LONDON (UNITED KINGDOM),sab 23 gennaio 2021 .RSC Adv.,2021,11,4555-4571 DOI 10.1039/D0RA10610K,Paper.Open AccessDesign,synthesis and biological evaluation of a series of Design,synthesis and biological evaluation of a series of new resveratrol analogues as potential anti-cancer agents Abstract A series of novel resveratrol derivatives were designed,synthesized and evaluated as anti-cancer agents.

Design,synthesis and biological evaluation of quinoline

Design,synthesis and biological evaluation of quinoline-indole derivatives as anti-tubulin agents targeting the colchicine binding site Eur J Med Chem.2019 Feb 1;163:428-442.doi 10.1016/j.ejmech.2018.11.070.Epub 2018 Nov 29.Authors Wenlong Li 1 Design,synthesis and investigation of potential anti 1.Int Immunopharmacol.2018 Aug;61:82-91.doi 10.1016/jtimp.2018.05.009.Epub 2018 May 28.Design,synthesis and investigation of potential anti-inflammatory activity of O-alkyl and O-benzyl hesperetin derivatives.

Design,synthesis and structure-activity relationship

Design,synthesis and structure-activity relationship studies of novel and diverse cyclooxygenase-2 inhibitors as anti-inflammatory drugs.Hayashi S(1),Ueno N,Murase A,Takada J.Author information (1)Pfizer Global Research Development,Nagoya Laboratories,Pfizer Japan Inc.,Design,synthesis,and anti-TMV bioactivities of (2017).Design,synthesis,and anti-TMV bioactivities of nucleobase phosphonate analogs.Phosphorus,Sulfur,and Silicon and the Related Elements Vol.192,No.12

Design,synthesis,and anti-inflammatory evaluation of a

Design,synthesis,and anti-inflammatory evaluation of a series of novel amino acid-binding 1,5-diarylpyrazole derivatives.Li MH(1),Yin LL,Cai MJ,Zhang WY,Huang Y,Wang X,Zhu XZ,Shen JK.Design,synthesis,and anti-melanogenic effects of (E)-2 Design,synthesis,and anti-melanogenic effects of (E)-2-benzoyl-3-(substituted phenyl)acrylonitriles Hwi Young Yun ,1 Do Hyun Kim ,1 Sujin Son ,1 Sultan Ullah ,1 Seong Jin Kim ,1 Yeon-Jeong Kim ,2 Jin-Wook Yoo ,1 Yunjin Jung ,1 Pusoon Chun ,2 and Hyung Ryong Moon 1

Design,synthesis,and biological evaluation of novel

Design,synthesis,and biological evaluation of novel arylcarboxamide derivatives as anti-tubercular agents Shahinda S.R.Alsayed ,a Shichun Lun ,b Giuseppe Luna ,a Chau Chun Beh ,c Alan D.Payne ,d Neil Foster ,c William R.Bishai * be and Hendra Gunosewoyo * aDesign,synthesis,and biological evaluation of novel Design,synthesis,and biological evaluation of novel arylcarboxamide derivatives as anti-tubercular agents Shahinda S.R.Alsayed ,a Shichun Lun ,b Giuseppe Luna ,a Chau Chun Beh ,c Alan D.Payne ,d Neil Foster ,c William R.Bishai * be and Hendra Gunosewoyo * a

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